The effects of BOTOX can last anywhere from 2 to 6 months, but, for most people, it lasts about 90 days. With regular use (3 to 4 times per year), the injected muscles will eventually thin or atrophy, making the treatments last several weeks longer.

The way in which the BOTOX is mixed can also affect the longevity of the treatment. If the product is diluted too much, it may not be effective. I like to mix the BOTOX with only a small amount of saline, so I can place the concentrated mixture exactly where I want it. This also reduces the possibility of it migrating to unwanted areas.

The effectiveness and longevity of the treatment is also affected by the way in which the product is handled and stored. Once mixed, BOTOX must be handled with care; if the mixture is agitated, it will not work as well. It is also best to keep it refrigerated.